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KMID : 0358219920190010041
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Korean Journal of Fertility and Sterility
1992 Volume.19 No. 1 p.41 ~ p.48
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Predictive Value of Serum B-hCG Level in Pregnancies following In vitro Fertilization and Embryo Transfer
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김석현
서창석/최두석/최영민/신창재/김정구/문신용/이진용/장윤석
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Abstract
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Serum level of βsubunit of human chorionic gonadotropin (β-hCG) was studied to evaluate its predictability of pregnancy outcome in 98 in vitro fertilization and embryo transfer (IVF-ET) patients using gonadotropin-releasing hormone (GnRH)
agonist.
Serial serum β-hCG levels were established for 42 singleton pregnancies, 20 normal multiple pregnancies, 18 preclinical abortions, 14 clinical abortions and 4 ectopic pregnancies.
In comparison to normal singleton pregnancies, multiple pregnancies showed significantly higher β-hCG levels on the post-ET day 10 to 13 and day 24 to 25. Clinical abortions did not show significantly lower β-hCG levels in early pregnancy
except
the
post-ET day 16-17, but showed significantly lower β-hCG levels from the post-ET day 22, compared with singleton pregnancies. Preclinical abortions showed significantly lower β-hCG levels than those of singleton pregnancies. Ectopic pregnancies
showed
lower β-hCG levels those of singleton pregnancies without statistical significance.
In conclusion, determination of serum β-hCG level in early pregnancy is a useful too for the prediction of preclinical abortions and multiple pregnancies and serial measurement of serum β-hCG levels will be helpful in predicting clinical
abortion.
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KEYWORD
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